True hermaphroditism or gonadal intersexuality. Cytogenetic and gonadal analyses of 5 new examples related to 67 known cases studied cytogenetically.

Two new cases of true hermaphroditism.

Child with True Hermaphroditism

True hermaphrodites possess both ovarian and testicular tissues which may be present in separate gonads or combined in an ovotestis. External and internal genitalia are ambiguous and variable, though a prominent penial structure is usual. Chromosome examination of true hermaphroditism has revealed an XX sex chromosome complement in the majority of cases, but the XY complement and different mosa...

Inhibin immunoreactivity in gonadal and non-gonadal tumors.

Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was fou...

Gonadal dysgenesis

Disorders of sex development (DSD), previously referred to as intersex disorders, comprise a variety of congenital diseases with anomalies of the sex chromosome, the gonads, the reproductive ducts and the genitalia. DSD is loosely classified into four groups on the basis of histological features of the gonadal tissue: XX-DSD with two ovaries (female pseudohermaphroditism), XY-DSD with two testi...

45,X/47,XXX/47,XX, del(Y)(p?)/46,XX mosaicism causing true hermaphroditism.

Sex differentiation in humans depends on the presence of the Y-linked gene SRY, which is activated in the pre-Sertoli cells of the developing gonadal primordium to trigger testicular differentiation. Occasionally testicular formation can take place in subjects lacking a Y chromosome resulting in a 46,XX sex reversal condition. True hermaphroditism (TH) is a rare form of intersexuality character...